AUGUST 30, 2007
VOLUME 4 NO. 14

PATIENTS & PRACTICE
WHAT TO TELL YOUR PATIENTS

OC reduces periods to four a year - is it safe?


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Only four periods a year. That's what Seasonale, the newly approved extended-use oral contraceptive (OC), promises your patients.

The prospect of fewer periods will have many of your patients eager to make the switch. Since OC efficacy has more or less been perfected, new developments are all about options. "I like to have more arrows in my quiver," says gynecologist Melissa Mirosh, a co-author of the Canadian Consensus Guideline on Continuous and Extended Hormonal Contraception. "With new products available, you can tailor the OC regimen to your patients' needs." But unlike regular OCs, Seasonale's long-term health effects are still a mystery.

Here's a list of FAQs your patients will likely throw at you about the new extended use pill.

How does it work? Seasonale comes in a 91-day pack, with 84 hormone pills and 7 placebo, instead of the 21/7 in cyclical OCs. Your patients will get their period once every three months, during those placebo days.

Who's it for? Women opt for an extended use pill like Seasonale for a range of reasons -- from medical conditions to lifestyle benefits, says Dr Mirosh. "People in the military, for instance, or athletes will be able to have fewer periods and have control over their occurrence," she explains. "And people who have very bad menstrual headaches will now have four bouts instead of 12 a year."

Who shouldn't take it? Seasonale is contraindicated for smokers over 35.

Does it work? "Seasonale has the same hormones as other OCs, so it works the same way," says Dr Mirosh. In terms of preventing pregnancy, your patients should know it's as effective as other OCs. In fact, it's a tiny bit better. The longer cycle makes it harder for the uterus lining to form, so there's nothing for the fertilized egg to latch on to. However, warn your patients that if they accidentally become pregnant, it'll be more difficult to tell with Seasonale.

Is it safe to stop periods? Ever since extended and continuous use pills appeared on the market, people have been debating whether it's safe (or natural) to stop a woman's cycle.

Women have been skipping the placebos and using cyclic pills back to back for many years, argues Dr Mirosh, "and we haven't seen any increase in significant side effects." She's confident Seasonale won't be any different.

But doctors at the UBC-based Society for Menstrual Cycle Research are worried about potential risks to breast, bone and cardiovascular health. The Society says we just don't know enough about the menstrual cycle's complex hormonal interactions to tamper with it.

Are there benefits to stopping menstruation? Having fewer periods can lower the risk of endometriosis and pelvic inflammatory disease. Both conditions are usually caused by menstruation and blood fragments that aren't cleared properly, leading to infection.

How about risks? The usual risks of OCs -- such as blood clots and stroke -- are still present with this pill.

Will I experience spotting? Tell your patients to expect some bleeding or spotting in the first few months. It should decrease over time. The same problem happens with Anya, the continuous-use OC that eliminates periods completely (not yet approved in Canada).

"The breakthrough bleeding rate with Anya is really high," says Dr Mirosh. "By having a period 'break' every three months with Seasonale, the bleeding is reduced."

Will stopping my periods make me infertile? Assure your patients their future fertility will not be affected. "They should start back to normal cycles within four to six weeks of being off the drug," says Dr Mirosh.

 

 

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