OCTOBER 30, 2005
VOLUME 2 NO. 18

PATIENTS & PRACTICE

Death hangs in filthy urban air

Despite tougher emission standards, smog still dominates city skies


Los Angeles has done much in recent years to curb its notorious smog problem, but new research shows its people continue to suffer a health hangover.

This study, in the November issue of the journal Epidemiology, finds that we had sorely underestimated air pollution's role in causing early death. The authors found chronic health effects of airborne particles are two to three times greater than previously believed.

"We have convincing evidence that those causes of death that we might expect from inflammation, ischemic heart disease and lung disorders, are elevated in areas of higher pollution levels," said lead author Michael Jerrett, associate professor of preventive medicine at the University of Southern California.

Twenty years of health records from 23,000 LA residents suggested that each increase of 10 micrograms per cubic metre (xg/m3) of fine particles in a neighbourhood's air raised all-cause mortality among participants by 11 to 17%, and mortality from ischemic heart disease by 25 to 39%.

The researchers followed 22,906 participants in the American Cancer Society's Cancer Prevention Study II, which ran from 1982 to 2000, by which time 5,856 had died. Their health outcomes were compared to pollution measurements taken over the years by nearly seventy monitoring devices spread around the city, which provided a detailed picture of pollution in each of 267 zip codes. The final analysis controlled for individual risk factors like smoking, diet and educational level.

NOT JUST BLOWING SMOKE
"By looking at the effects of pollution within communities, not only did we observe pollution's influence on overall mortality, but we saw specific links between particulate matter and death from ischemic heart disease, such as heart attack, as well as lung cancers," said Dr Jerrett.

The pollutants measured were all particles smaller than 2.5 micrometres in diameter. These "PM2.5" particles pose the greatest health risk, as they can easily enter the lung and in some cases the bloodstream. Within Los Angeles, local levels can vary by as much as 20 xg/m3, enough to produce significant differences in mortality according to these findings.

Car exhaust fumes are prime culprits, Dr Jerrett says. "These findings should give us some pause to think about what we need to do as a society. Restrictions on tailpipe emissions have gotten tighter, but there are more trucks and cars on the roads and people are driving farther." He adds, "This study may cause us to reflect on how we use our cars, what cars we drive and whether we can do anything to make tailpipe emissions from all vehicles less harmful to health."

OZONE OFF THE HOOK
But despite the emphasis on cars, one automobile by-product is exonerated. Ozone levels were also measured by the researchers, but surprisingly, proved to have no influence on health outcomes.

The study was supported by the National Institute of Environmental Health Sciences, which is also behind another study of LA pollution in the same issue of Epidemiology. Researchers looked at the link between pollution and asthma in 208 children who were part of the Children's Health Study, which has tracked children's respiratory health since 1993.

DON'T PLAY NEAR TRAFFIC
Looking at data from 10 California cities, researchers found that proximity to a freeway was directly correlated to nitrogen dioxide levels, which in turn translated to higher asthma risk. For each increase of 5.7 parts per billion in average NO — about the gap between the cleanest and most polluted areas in the study — the risk of asthma increased by 83%. And for every 1.2 kilometres closer the students lived to the freeway, asthma risk went up by 89%.

"These results have both scientific and public health implications," said Dr David Schwartz, director of the National Institute of Environmental Health Sciences. "They strengthen an emerging body of evidence that air pollution can cause asthma, and that exposure to outdoor levels of nitrogen dioxide and other traffic-related air pollutants may be a significant risk factor for this illness."

Lead author Dr James Gauderman echoed the sentiments of his USC colleague Dr Jerrett. "Considering the enormous costs associated with childhood asthma, today's public policy toward regulating pollutants may merit some re-evaluation."

 

 

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