SEPTEMBER 15, 2004
VOLUME 1 NO. 16
 

Steroids work at doses so low they can't be detected

Competitive athletes are no dopes when it comes to avoiding drug detection


The Olympics are upon us once again, and the essential question arises: are these people really tributes to the human spirit or are they just lycra-encased walking drug cabinets? All athletes deny taking performance-enhancing drugs, but many of them seem to suggest that all of their competitors are juiced to the eyeballs, skilfully avoiding detection by hypersensitive tests. So how do they get away with it?

Research commissioned by the New Scientist and carried out by Dr Robert Weatherby of Southern Cross University, New South Wales and colleagues set out to answer this question. Of the 24 athletes recruited, six functioned using legal performance aids � caffeine, pseudoephedrine, colostrum, creatine, tribulus (a tropical root extract) and the hypoxicator (a breathing device used to simulate altitude training). The remaining 18 athletes were blindly randomized to take either placebo or testosterone enanthate at a dose about 50 times lower than that typically found in professional athletes. Researchers then measured changes to athletic performance, mood and immune response.

Despite such tiny doses, Dr Weatherby found that the maximum performance boost came after just three weeks, as opposed to the anecdotal 10 weeks steroids are supposed to take to kick in. At this stage, the testosterone subjects had improved their bench press performance over baseline by 8.2% compared to 1.8% for placebo subjects. Their 10-second total power output on a stationary cycle had risen by 8.1% compared to just 0.1% in placebo subjects.

Recent media attention has focussed on synthetic steroids, but natural testosterone use is still "rampant" in sports, according to Canada's chief doping tester, Professor Christiane Ayotte of the Montreal Doping Control Laboratory.

In some ways abuse of the natural hormone is harder to detect. Finding evidence of testosterone injection relies on measuring the TE ratio, the ratio between active and inactive forms in a urine sample. This number typically doesn't rise above one in normal people. In doping athletes it can go up to 10, or temporarily fall below one if they stop injecting. But at the levels seen in this study, detection would rapidly become impossible.

Athletes who follow Dr Weatherby's doping regimen would very likely escape detection, and he firmly believes they would improve their chances of winning. Nonetheless, just as the performance benefits of steroids appear at lower than expected doses, so do the negative consequences.

Even at these low doses, said Dr Weatherby, "the body's ability to defend itself against viruses and cancers is likely to be significantly lessened." Moreover, psychological analysis showed a steady decline in empathy and consideration for others.

Far from being a tribute to the greatness of the human spirit, many elite athletes may find their own spirits stunted by the drugs that build their muscles, becoming instead an homage to humanity's sneakiness and thirst for glory.

 

 

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